The American Cancer Society recommends the following:

Most cases of endometrial cancer cannot be prevented, but there are some things that may lower your risk of developing this disease.

One way to lower endometrial cancer risk is to change risk factors whenever possible. For example, weight loss may reduce the risk of this type of cancer in those who are obese. Controlling diabetes may also help reduce the risk. If you have any of these conditions, discuss them with your doctor.

A healthy diet and exercise can also lower endometrial cancer risk. Women who exercise on a daily basis can cut their risk in half compared to women who don't exercise. As mentioned in the risk factor section, maintaining a healthy body weight can substantially reduce your risk for this cancer.

Estrogen to treat the symptoms of menopause is available in many different forms like pills, skin patches, creams, and vaginal rings. If you are thinking about using estrogen for menopausal symptoms, ask your doctor about how it will affect your risk of endometrial cancer. Progestins (progesterone-like drugs) can reduce the risk of endometrial cancer in women taking estrogen therapy, but this combination increases the risk of breast cancer. If you still have your uterus and are taking estrogen therapy, discuss this issue with your doctor.

Getting proper treatment of pre-cancerous disorders of the endometrium is another way to lower the risk of endometrial cancer. Most endometrial cancers develop over a period of years. Many are known to follow and possibly start from less serious abnormalities of the endometrium called endometrial hyperplasia (see the section, "What are the risk factors for endometrial cancer?"). Some cases of hyperplasia will go away without treatment. Sometimes hyperplasia needs to be treated with hormones or even surgery. Treatment with progestins and a dilation and curettage (D & C) or hysterectomy can prevent hyperplasia from becoming cancerous. (D & C is described in the section, "How is endometrial cancer diagnosed?"). Abnormal vaginal bleeding is the most common symptom of endometrial pre-cancers and cancers, and it needs to be reported and evaluated right away.